Allyl chloride → HCID 12509100, compound

Participants

Reaction Steps

1.6 g. of 2-(1-imidazolyl)-phenol [Khim. Geterotsikl. Soedin Akad. Nauk Latv. SSR 1966, 143; Chem. Abstr. 65 (1966) 13686] is dissolved in 20 ml. of dimethylformamide and combined with 300 mg. of a sodium hydride - oil suspension (80%). The mixture is agitated for one hour at room temperature, and then 760 mg. of allyl chloride is added thereto. After three hours of agitation at room temperature, the solution is added to 100 ml. of 1N sulfuric acid and extracted with ether. The aqueous phase is rendered alkaline with 40% sodium hydroxide solution and extracted with methylene chloride. After drying and evaporation of the solvent, the crude product is dissolved in a small amount of methanol and combined with methanolic hydrochloric acid until a weakly acidic reaction is observed. After the solvent has been evaporated under vacuum, the residue is dissolved in methylene chloride and mixed with ether until the onset of crystallization.

Provenance & Evidence