反应详情

A solution of methylhydrazine (0.3 mole) in methylene chloride (150 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 5-t-Butyl-1,3,4-thiadiazol-2-yl isocyanate dimer (0.1 mole) is then added, with stirring, at room temperature. After the addition is completed the reaction mixture is heated at reflux for a period of about 4 hours. After this time the reaction mixture is stripped of solvent and excess hydrazine to yield the desired product 2-methyl-4-(5-t-butyl-1,3,4-thiadiazol-2-yl)semicarbazide as the residue.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. additionAfter the addition
4. temperatureis heated
5. temperatureat reflux for a period of about 4 hours