2-Fluorophenyl isocyanate → HCID 54351266, compound

Participants

Reaction Steps

To 35 g (0.27 mol) of 1-methyl-3-methoxy urea in 150 ml xylene was added dropwise a solution of 37 g (0.27 mol) 2-fluorophenylisocyanate in 100 ml of xylene. The reaction mixture was refluxed for 4 hours. The reaction mixture was filtered while warm to remove a small amount of triethylamine hydrochloride (impurity in the urea reactant). The filtrate was evaporated to give the biuret product as a solid (m.p. 144°-147° C after recrystallization from benzene). Elemental analysis for fluorine showed: calc. 7.88%, found 7.64%.

Provenance & Evidence