Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol | HCID 545700 | — |
| Product | HCID 21454932 | HCID 21454932 | — |
Reaction Steps
To 84 g. (1.0 mole) of diketene contained in a three-necked round-bottom flask fitted with a mechanical stirrer addition funnel and reflux condenser and heated to 50° C. is added 500 mg. of sodium acetate followed by 175.2 g. (1.0 mole) of N-methyl-N-t-butyloxycarbonylethanolamine over a period of 20-30 minutes. The reaction mixture is allowed to stir at room temperature for 1 hour, after which it is distilled under reduced pressure to provide the desired product, 2-(N-methyl-N-t-butyloxycarbonylamino)ethyl acetoacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04007184 |
|---|
| Source dataset | uspto-grants-1977_02 |
|---|
| ORD ID | ord-4b3af576750d43a89f08677e4ef66727 |
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| Source note | uspto-grants-1977_02 |
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