Water → HCID 23667351, compound

HRID 435975Notes

Reaction equation

HRID 435975 reaction equation
[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:9]=2)[CH2:4]1)[CH3:2].[OH-].[Na+:18].O>C(O)C>[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:12]([CH3:16])[C:13]([O-:15])=[O:14])[CH:9]=2)[CH2:4]1)[CH3:2].[Na+:18]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 12627897HCID 12627897, compound

Product 1

HCID 23667351HCID 23667351, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 12.2g. of 2-(2-ethylindan-5-yl)propionic acid was added a solution of 2.2g. of sodium hydroxide in 9 ml. of water and 21 ml. of ethanol. After complete dissolution, the solvent was distilled off under reduced pressure and to the residue was added ether. The precipitates thus separated were recovered by filtration and washed with either to give 12.9g. of a white powder. The powder was recrystallized from a mixture of ethanol and ether to give the desired product as white needles of m.p. 178° - 181° C.

Workup

  1. dissolutionAfter complete dissolution
  2. distillationthe solvent was distilled off under reduced pressure and to the residue
  3. additionwas added ether
  4. customThe precipitates thus
  5. customseparated
  6. filtrationwere recovered by filtration
  7. washwashed with either
  8. customto give 12.9g
  9. customThe powder was recrystallized from a mixture of ethanol and ether

Sources & evidence

ORD record
ord-3d6ca3794d394bc492a12a0d95665ca2
Source dataset
uspto-grants-1977_02
Patent number
US04007179

Reaction notes

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