Tert-Butylamine → HCID 12671207, compound

Participants

Reaction Steps

A mixture of 2.4g of 7-chloro-6-(2-chloropropyl)-5-methyl-s-triazolo[1,5-a]pyrimidine, 0.9g of tert-butylamine, 1.8g of sodium carbonate and 20 ml of ethanol was stirred for 3 hours at room temperature and then refluxed for 5 hours. The hot reaction mixture was filtered, the filtrate was concentrated under reduced pressure and the residue was purified by a column chromatography of alumina. To an oily substance thus obtained was added a solution of hydrogen chloride-ethanol and the crystals precipitated thereby were collected by filtration.

Provenance & Evidence