HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(Hydroxymethyl)-7-methoxy-9H-xanthen-9-OL
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Ethyl 7-methoxy-9-oxoxanthene-2-carboxylate | HCID 21455094 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(Hydroxymethyl)-7-methoxy-9H-xanthen-9-OL | HCID 21455095 | 84% |
Reaction Steps
Lithium aluminum hydride (500 mg) was added to a stirred solution of ethyl 7-methoxy-9-oxoxanthene-2-carboxylate (1g) in THF (100 ml). The reaction mixture was stirred at room temperature under nitrogen for 5 hours. Water and MgSO4 were added. The inorganic solids were filtered off and washed with ethyl acetate. The filtrate and washings were combined and evaporated to give the crude product. Recrystallization from ethyl acetate gave white crystals (0.82 g, 84%), mp. 142°-143°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04007205 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-67a38b1b31974630bd45356f0540d6db |
| Source note | uspto-grants-1977_02 |