Sodium Hydroxide → HCID 21454960, compound

HRID 436016Notes

Reaction equation

HRID 436016 reaction equation
[N:1]([N:3]1[CH:8]([CH:9]2[CH2:14][CH2:13][CH:12]([Cl:15])[CH2:11][N:10]2C(=O)C(F)(F)F)[C:7](=[O:22])[N:6]([N:23]=[O:24])[CH:5]([CH:25]2[CH2:30][CH2:29][CH:28]([Cl:31])[CH2:27][N:26]2C(=O)C(F)(F)F)[C:4]1=[O:38])=[O:2].[OH-].[Na+]>C(Cl)(Cl)Cl>[N:23]([N:6]1[CH:5]([CH:25]2[CH2:30][CH2:29][CH:28]([Cl:31])[CH2:27][NH:26]2)[C:4](=[O:38])[N:3]([N:1]=[O:2])[CH:8]([CH:9]2[CH2:14][CH2:13][CH:12]([Cl:15])[CH2:11][NH:10]2)[C:7]1=[O:22])=[O:24]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21454955HCID 21454955, compound

Product 1

HCID 21454960HCID 21454960, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A 1 mmole portion of 1,4-dinitroso-3,6-bis-(1-trifluoracetyl-5-chloro-2-piperidinyl)-2,5-piperazinedione is stirred in a 2-phase system of 10ml. of chloroform and 10 ml. of 0.2 N sodium hydroxide with ice-bath cooling for 4 hours. The solvents are then removed in vacuo and the residue is chromatographed on silica gel tic plates to afford 1,4-dinitroso-3,6-bis-(5-chloro-2-piperdinyl)-2,5-piperazinedione.

Workup

  1. customThe solvents are then removed in vacuo
  2. customthe residue is chromatographed on silica gel tic plates

Sources & evidence

ORD record
ord-be014a2dd56e4f378546766f36f0f510
Source dataset
uspto-grants-1977_02
Patent number
US04007190

Reaction notes

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