HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(3-methoxy-4-nitrophenyl)-5-methyl-1,3-oxazole-4-carboxylate → Methyl 2-(4-amino-3-methoxyphenyl)-5-methyl-1,3-oxazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(3-methoxy-4-nitrophenyl)-5-methyl-1,3-oxazole-4-carboxylate | HCID 68405823 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(4-amino-3-methoxyphenyl)-5-methyl-1,3-oxazole-4-carboxylate | HCID 67549647 | 100.9% |
Reaction Steps
The same operation as in Example (95b) was performed using methyl 2-(3-methoxy-4-nitrophenyl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (105c) (0.75 g, 2.57 mmol), 10% Pd/C (0.2 g) and methanol (20 mL), to obtain 0.68 g of the title compound as a yellow solid (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-7011432aa0084d8c816096b69f86cb54 |
| Source note | uspto-grants-2013_09 |