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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43613Generated: October 28, 2026

Thionyl Chloride → HCID 67549048, compound

https://huagongshe.com/reaction/43613

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant4-chloro-5-ethyl-1H-imidazole-2-carboxylic acidHCID 67548929—
ReactantMethyl 2-(4-amino-3-methoxyphenyl)-5-methyl-1,3-oxazole-4-carboxylateHCID 67549647—
SolventPyridineHCID 1049—
ProductHCID 67549048HCID 6754904871%

Reaction Steps

The same operation as in Example (91c) was performed using 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid (0.135 g, 0.78 mmol), thionyl chloride (4 mL), methyl 2-(4-amino-3-methoxyphenyl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (105d) (0.3 g, 1.03 mmol) and pyridine (5 mL), to obtain 0.23 g of the title compound as a colorless solid (71%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-9b92eb25a7d14c16855211644459e0d8
Source noteuspto-grants-2013_09