反应详情

A solution of 3.4 g. of 2-methylamino-3-aminopyridine and 2.9 g. of methyl tetrahydro-4-oxo-3-thiophene carboxylate in 200 ml. of toluene is heated under reflux for 3 hours, during which 100 ml. of distillate is collected in a Dean-Stark trap. The solution is concentrated under reduced pressure and the solid residue is recrystallized from ethyl acetate to give pale yellow crystals, m.p. 240°-241° C.

1. temperatureunder reflux for 3 hours, during which 100 ml
2. distillationof distillate is collected in a Dean-Stark trap
3. concentrationThe solution is concentrated under reduced pressure
4. customthe solid residue is recrystallized from ethyl acetate
5. customto give pale yellow crystals, m.p. 240°-241° C.