Thionyl Chloride → HCID 12944294, compound

HRID 436156Notes

Reaction equation

HRID 436156 reaction equation
O[CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]([OH:13])=[O:12])[C:5]=2[CH2:4][CH2:3]1.S(Cl)([Cl:16])=O>C1C=CC=CC=1>[Cl:16][CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]([OH:13])=[O:12])[C:5]=2[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 12944293HCID 12944293, compound

Product 1

HCID 12944294HCID 12944294, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 30 ml. of benzene is added 5.35 g. of 1-hydroxyindan-4-carboxylic acid. Following the addition of 15 ml. of thionyl chloride, the mixture is stirred for 3 hours. Then, the reaction mixture is concentrated to dryness under reduced pressure and the resultant crystals are recrystallized from benzene. The described procedure gives 1-chloroindan-4-carboxylic acid melting at 135.5°-137.5° C.

Workup

  1. additionthe addition of 15 ml
  2. concentrationThen, the reaction mixture is concentrated to dryness under reduced pressure
  3. customthe resultant crystals are recrystallized from benzene

Sources & evidence

ORD record
ord-bdad92ba24bd433492f3bcdfcb361c3a
Source dataset
uspto-grants-1977_02
Patent number
US04007225

Reaction notes

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