Hydrochloric Acid → 52406-24-3

Participants

Reaction Steps

200 g of 3,3-bis(4'-hydroxy-3'-tert.-butylphenyl)butanoic acid methyl ester (m.p. 82° C) were added to a solution of 40 g of sodium hydroxide in 600 ml of ethanol and the mixture was refluxed. After cooling to room temperature, the mixture was acidified with hydrochloric acid. The alcohol was removed by distillation and the solid residue was dissolved in hot toluene. The hot solution was filtered. Upon cooling, the 3,3-bis(4'-hydroxy-3'-tert.butyl-phenyl)butanoic acid precipitated from the toluene solution, m.p. 156° C.

Provenance & Evidence