Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2,6-Di-tert-butylphenol | HCID 31405 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Terbuficin | HCID 3084235 | — |
Reaction Steps
103 g of 2,6-di-tert.-butyl-phenol (0.5 mol) and 21 g of glyoxylic acid (0.25 mol) of (CHO.COOH) . 1/2 H2O) were dissolved in 300 ml of carbon tetrachloride and stirred at 50° C for about 40 hours. During the first 6 hours, a weak hydrogen chloride stream was passed through the solution, later saturation was completed from time to time by feeding in hydrogen chloride. After condensation was complete, the solvent was eliminated. The product obtained in a pasty form was dissolved and precipitated several times from hexane. The crystallized compound having a faint yellowish tinge melted at 211° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04007282 |
|---|
| Source dataset | uspto-grants-1977_02 |
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| ORD ID | ord-34607cfc7e914cb09c42e026741d5972 |
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| Source note | uspto-grants-1977_02 |
|---|
