Dichloromethane → HCID 21455283, compound

HRID 436198Notes

Reaction equation

HRID 436198 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.C(Cl)Cl>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 21455293HCID 21455293, compound

Product 1

HCID 21455283HCID 21455283, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-(3-Benzyloxyphenyl)-5H-s-triazolo[5,1-a] isoindole (17 g) is suspended in 500 ml of ethanol and hydrogenated at atmospheric pressure and room temperature in the presence of 3 g of 10% Pd on charcoal. After addition of 500 ml of methylene chloride, the catalyst is filtered off and the solution is concentrated to dryness. The title product is purified by crystallization from dioxane. Yield 10.68 g (85.7%); m.p. 251-2°C.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe solution is concentrated to dryness
  3. customThe title product is purified by crystallization from dioxane

Sources & evidence

ORD record
ord-9a82c6f61a1e4f68bfca44da947ee874
Source dataset
uspto-grants-1977_02
Patent number
US04007276

Reaction notes

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