Dichloromethane → HCID 70606043, compound

Participants

Reaction Steps

To 0.391 g. (1.mmol.) of mercuric acetate in a mixture of 15 ml. of methylene chloride and 15 ml. of acetic acid was added, as a neat solid, 0.435 g. (1 mmol.) of t-butyl 3-hydroxy-4-bromo-2-(2-formylthio-4-oxo-3-phenoxyacetamido-1-azetidinyl)-2-butenoate. The resulting mixture was stirred for five minutes at room temperature after which time the solution became cloudy. Hydrogen sulfide was bubbled into the mixture, and the mixture was filtered through a filter aide an charcoal. The filtrate was evaporated to a residue to obtain t-butyl 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate.

Provenance & Evidence