Propionic Acid → HCID 131710649, compound

Participants

Reaction Conditions

Reaction Steps

To 0.430 g. (1.1 mmol.) of mercuric acetate in a mixture of 20 ml. of toluene and 10 ml. of propionic acid are added 0.632 g. (1 mmol.) of 3-hydroxy-4-bromo-2-[2-formylthio-4-oxo-3-(α-benzyloxycarbonylaminophenylacetamido)-1-azetidinyl]-2-butenoate, p-methoxybenzyl ester, in 20 ml. of toluene. The mixture is stirred for 30 minutes at 15° C., after which time the solution becomes cloudy. Hydrogen sulfide is bubbled into the mixture, and the mixture then is filtered through activated charcoal and a filter aide. The resulting filtrate is evaporated, and a residue comprising p-methoxybenzyl 7-(α-benzyloxycarbonylaminophenylacetamido)-3-hydroxy-3-cephem-4-carboxylate is obtained.

Provenance & Evidence