Butyric Acid → HCID 67834215, compound

Participants

Reaction Conditions

Reaction Steps

To 0.410 g. (1.05 mmol.) of mercuric acetate in a mixture of 10 ml. of chloroform and 10 ml. of butyric acid are added 0.529 g. (1 mmol.) of 3-hydroxy-4-bromo-2-(2-formylthio-4-oxo-3-phenylacetamido-1-azetidinyl)-2-butenoate, benzhydryl ester, in 10 ml. of chloroform. The mixture is stirred for 15 minutes at 10° C., after which time the solution becomes cloudy. Ethyl mercaptan is added to the mixture, and the mixture then is filtered through activated charcoal and a filter aide. The resulting filtrate is evaporated, and a residue comprising benzhydryl 7-phenylacetamido-3-hydroxy-3-cephem-4-carboxylate is obtained.

Provenance & Evidence