Isobutyric Acid → HCID 131710653, compound

Participants

Reaction Conditions

Reaction Steps

To 0.391 g. (1 mmol.) of mercuric acetate in a mixture of 15 ml. of toluene and 15 ml. of isobutyric acid are added 0.739 g. (1 mmol.) of 3-hydroxy-4 -bromo-2-[2-formylthio-4-oxo-3-(α-benzhydryloxycarbonylphenylacetamido)-1-azetidinyl]-2-butenoate, benzhydryl ester, as a neat solid. The mixture is stirred for 20 minutes at 18° C., after which time the solution becomes cloudy. n-Propyl mercaptan is added to the mixture, and the mixture then is filtered through activated charcoal and a filter aide. The resulting filtrate is evaporated, and a residue comprising benzhydryl 7-(α-benzhydryloxycarbonylphenylacetamido)-3-hydroxy-3-cephem-4-carboxylate is obtained.

Provenance & Evidence