Acetic Anhydride → HCID 21454035, compound

HRID 436273Notes

Reaction equation

HRID 436273 reaction equation
[C:1]1([C:7]2[CH:11]=[C:10]([S:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>S(=O)(=O)(O)O>[C:19]([N:9]1[C:10]([S:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:11][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8]1)(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178420559HCID 178420559, compound

Product 1

HCID 21454035HCID 21454035, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

At 20° to 25° C, a few drops of concentrated sulfuric acid are added to a solution of 10 parts of 3-phenyl-5-phenylthiopyrazole in 100 parts of acetic anhydride. After 15 hours the solution is concentrated in vacuo and 50 parts of water is added to the residue. There is obtained 10.5 parts (90% of theory) of 1-acetyl-3-phenyl-5-phenylthiopyrazole; m.p.: 83° to 84.5° C (recrystallized from methanol).

Workup

  1. concentrationAfter 15 hours the solution is concentrated in vacuo and 50 parts of water
  2. additionis added to the residue

Sources & evidence

ORD record
ord-518dfa9df3c94887b4ecdbc9f0479626
Source dataset
uspto-grants-1977_02
Patent number
US04008249

Reaction notes

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