Bromine → HCID 178419283, compound

HRID 436274Notes

Reaction equation

HRID 436274 reaction equation
[Br:1]Br.[C:3]1([C:9]2[CH:13]=[C:12]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[NH:11][N:10]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)(=O)C>[C:3]1([C:9]2[C:13]([Br:1])=[C:12]([S:14][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:11][N:10]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 178420559HCID 178420559, compound

Product 1

HCID 178419283HCID 178419283, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

At 25° C, 8 parts of bromine is slowly added, with stirring, to a solution of 12.6 parts of 3-phenyl-5-phenylthiopyrazole in 150 parts of glacial acetic acid. After 12 hours, the solution is concentrated in vacuo and the residue treated with about 50 parts of water. There is obtained 16 parts (96.7% of theory) of 3-phenyl-4-bromo-5-phenylthiopyrazole; m.p.: 121° to 122° C (recrystallized from cyclohexane).

Workup

  1. concentrationthe solution is concentrated in vacuo
  2. additionthe residue treated with about 50 parts of water

Sources & evidence

ORD record
ord-5574993546ab420883d0db1cf2c2eb2e
Source dataset
uspto-grants-1977_02
Patent number
US04008249

Reaction notes

Loading…