HCID 53671047, compound → HCID 21454052, compound

HRID 436283Notes

Reaction equation

HRID 436283 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:7]3[C:15]([CH2:16][CH2:17][C:18]=2[CH:19]=1)=[C:14]1[C:10]([C:11]([CH3:21])([CH3:20])[CH2:12][CH2:13]1)=[CH:9][CH:8]=3>O>[CH3:20][C:11]1([CH3:21])[C:10]2[C:14](=[C:15]3[C:7](=[CH:8][CH:9]=2)[C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:19][C:18]=2[CH2:17][CH2:16]3)[CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 53671047HCID 53671047, compound

Product 1

HCID 21454052HCID 21454052, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 26 parts of 7,15,16,17-tetrahydro-3-methoxy-17,17-dimethyl-6H-cyclopenta[ a]phenanthrene (Bull. soc. chim. France, 1968, 4886) and 150 parts of freshly-fused pyridine hydrochloride is heated in an atmosphere of nirogen at 220° for 1 1/2 hours. The reaction mixture is then poured into 200 parts of water, whereupon insoluble solids are filtered out, washed with water, dried in air, and crystallized from a mixture of ether and hexane to give 7,15,16,17-tetrahydro-17,17-dimethyl-6H-cyclopenta[a]phenanthren-3-ol melting at approximately 152°-153°, and having the formula ##STR6##

Workup

  1. temperatureis heated in an atmosphere of nirogen at 220° for 1 1/2 hours
  2. filtrationare filtered out
  3. washwashed with water
  4. customdried in air
  5. customcrystallized from a mixture of ether and hexane

Sources & evidence

ORD record
ord-26d4a9b258cb4d02bc4a1f2e5854f578
Source dataset
uspto-grants-1977_02
Patent number
US04008257

Reaction notes

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