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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43629Generated: October 29, 2026

Methanol → HCID 59615429, compound

https://huagongshe.com/reaction/43629

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantLithium HydroxideHCID 3939—
ReactantMethyl 2-(4-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methylphenyl)-5-methyl-1,3-oxazole-4-carboxylic acidHCID 68406197—
SolventTetrahydrofuranHCID 8028—
ProductHCID 59615429HCID 5961542986%

Reaction Steps

The same operation as in Example (91d) was performed using methyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methylphenyl)-5-methyl-1,3-oxazole-4-carboxylate obtained in Example (108f) (0.12 g, 0.30 mmol), 2 N lithium hydroxide (3 mL, 6 mmol), methanol (5 mL) and tetrahydrofuran (5 mL), to obtain 0.10 g of the title compound as a colorless solid (86%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-56ff7b44be734f92a4bb8ad29e2ae0e8
Source noteuspto-grants-2013_09