Sodium borohydride → HCID 23456191, compound

HRID 436323Notes

Reaction equation

HRID 436323 reaction equation
[O:1]=[C:2]1[C:9]2[C:5](=[C:6]([CH3:17])[N:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]=2[CH3:10])[CH2:4][CH2:3]1.[BH4-].[Na+]>C(O)C>[OH:1][CH:2]1[C:9]2[C:5](=[C:6]([CH3:17])[N:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]=2[CH3:10])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 12894369HCID 12894369, compound

Product 1

HCID 23456191HCID 23456191, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1.5 g. (0.067 mole) of 4-oxo-1,3-dimethyl-2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrole, described above in Example 10, and 254 mg. (0.0067 mole) of sodium borohydride in 15 ml. of ethanol was stirred for sixteen hours at 0°-5° C., then for an additional eight hours at ambient temperature and poured into ice/water. The mixture was extracted with ether, and the ether extracts were dried and evaporated to dryness to give 4-hydroxy-1,3-dimethyl-2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrole as an oil.

Workup

  1. extractionThe mixture was extracted with ether
  2. dry with materialthe ether extracts were dried
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-b649cff8fb844dd8a55e349ee424d3ef
Source dataset
uspto-grants-1977_02
Patent number
US04008250

Reaction notes

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