Methanol → 2-(4-Carbomethoxyphenyl)-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-4-carboxamide
Reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]([CH3:15])=[C:13]3[C:16]([CH3:24])([C:21]([NH2:23])=[O:22])[CH2:17][C:18]([CH3:20])([CH3:19])[C:12]3=[C:11]2[CH3:25])=[CH:6][CH:5]=1)([OH:3])=[O:2].[CH3:26]O>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14]([CH3:15])=[C:13]3[C:16]([CH3:24])([C:21]([NH2:23])=[O:22])[CH2:17][C:18]([CH3:19])([CH3:20])[C:12]3=[C:11]2[CH3:25])=[CH:8][CH:9]=1)([O:3][CH3:26])=[O:2]Participants
3
Procedure
Reaction of the 2-(4-carboxyphenyl)-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-4-carboxamide described above in Example 20BZ with methanol in the presence of a small amount of a mineral acid affords 2-(4-carbomethoxyphenyl)-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-4-carboxamide.
Sources & evidence
- ORD record
- ord-a9fb77a768694aa08e6334c43cbca34d
- Source dataset
- uspto-grants-1977_02
- Patent number
- US04008250
Reaction notes
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