Propargyl bromide → HCID 20362381, compound

HRID 436328Notes

Reaction equation

HRID 436328 reaction equation
[CH2:1]([Br:4])[C:2]#[CH:3].[CH3:5][C:6]1[N:7]2[CH2:13][CH2:12][N:11]=[C:8]2[S:9][CH:10]=1>C(#N)C>[Br-:4].[CH2:1]([N:11]1[C:8]2[S:9][CH:10]=[C:6]([CH3:5])[N+:7]=2[CH2:13][CH2:12]1)[C:2]#[CH:3]

Participants

4

Reactant 2

HCID 7842Propargyl bromideHCID 4137003-Methyl-5,6-dihydroimidazo(2,1-b)(1,3)thiazole

Product 1

HCID 20362381HCID 20362381, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 12 g. of propargyl bromide and 14 g. of 3-methyl-5,6-dihydroimidazo[2,1-b]thiazole (prepared by basification of 3-methyl-5,6-dihydroimidazo [2,1-b]thiazole hydrochloride with 5N sodium hydroxide solution) in 160 ml. of dry acetonitrile is allowed to stir at room temperature for 16 hrs. The solution is concentrated to a small volume and the precipitated product filtered. The purified product is obtained by recrystallization from acetonitrile-ethyl acetate, 21 g., m.p. 207°-208° C.

Workup

  1. concentrationThe solution is concentrated to a small volume
  2. filtrationthe precipitated product filtered
  3. customThe purified product is obtained by recrystallization from acetonitrile-ethyl acetate, 21 g

Sources & evidence

ORD record
ord-e4236b0f13b24339907b979850b13f0a
Source dataset
uspto-grants-1977_02
Patent number
US04008245

Reaction notes

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