Hydrochloric Acid → N-(2-methyl-4-nitrophenyl)ethane-1,2-diamine hydrochloride

Participants

Reaction Steps

51.45 g (0.3 mole) of 2-chloro-5-nitro-toluene is added to 200 cm3 (2.5 moles) ethylenediamine hydrate. The mixture is heated at reflux for 5 hours, and the excess of ethylene diamine is then eliminated under vacuum. The residue is treated with 300 cm3 of a 5N solution of hydrochloric acid, Drying yields 60.5 g of 4-nitro-2-methyl-N-(β-aminoethyl)aniline monohydrochloride, which is washed with acetone.

Provenance & Evidence