HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-nitro-2-methoxy-N-(beta-aminoethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | 2-Chloro-5-nitroanisole | HCID 70519 | — |
| Reactant | Ethylenediamine monohydrate | HCID 12200817 | — |
| Product | 4-nitro-2-methoxy-N-(beta-aminoethyl)aniline | HCID 21454199 | 86.1% |
Reaction Steps
31 g (0.165 mole) of 2-chloro-5-nitro-anisole is added to 130 cm3 (1.65 mole) ethylenediamine hydrate. The reaction mixture is heated at reflux for five hours, and the excess of ethylenediamine driven off under vacuum. The residue is treated with 200 cm3 of a 5N hydrochloric acid solution, and dried, yielding 30 g of 4-nitro-2-methoxy-N(β-aminoethyl) aniline, which is washed with acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04008272 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-9f073526c25e487a8ba76f1aeac338f3 |
| Source note | uspto-grants-1977_02 |