Hydrochloric Acid → Alpha,alpha,alpha-trifluoro-O-toluidine hydrochloride

Participants

Reaction Conditions

Reaction Steps

An aqueous solution of o-aminobenzotrifluoride hydrochloride was prepared by the addition of o-aminobenzotrifluoride (1 mole; 161.1 grams) to 37% hydrochloric acid (10.8 moles; 1232 grams) at 24° C-36° C. Hydrogen peroxide (35.3%; 1.18 moles; 113.7 grams) was added dropwise over a 0.5 hour period (initial temp., 29° C; final temp. 81° C) and then maintained at 70° C-80° C for an additional 0.5 hour period. The acidic solution was neutralized with 50% sodium hydroxide (pH 10) and the contents steam distilled to give 198.0 grams of an organic product, wt. 198.0 grams.

Provenance & Evidence