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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43636Generated: October 29, 2026

Methanol → HCID 59615429, compound

https://huagongshe.com/reaction/43636

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantLithium HydroxideHCID 3939—
ReactantMethyl 2-(4-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylateHCID 67549102—
SolventTetrahydrofuranHCID 8028—
ProductHCID 59615429HCID 5961542980%

Reaction Steps

The same operation as in Example (91d) was performed using methyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate obtained in Example (109f) (0.13 g, 0.33 mmol), 2 N lithium hydroxide (3 mL, 6 mmol), methanol (3 mL) and tetrahydrofuran (5 mL), to obtain 0.10 g of the title compound as a colorless solid (80%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-c6c2d670a1144a3eae870d4ca1764b3e
Source noteuspto-grants-2013_09