HCID 70634572, compound → HCID 70634676, compound

Participants

Reaction Steps

300 mg. of 6α-fluoro-11β-hydroxy-21-hexanoyloxy-16α-methyl-1,4,8-pregnatriene-3,20-dione is dissolved in 7.5 ml. of acetone, combined with 0.36 ml. of a chromium (VI) oxide solution, and stirred for 1 hour at room temperature. The reaction solution is stirred into ice water; the thus-formed precipitate is vacuum-filtered and dissolved in methylene chloride. The methylene chloride solution is washed neutral, dried, and evaporated under vacuum. The crude product is purified by chromatography, and recrystallization from hexane-acetone yields 6α-fluoro-21-hexanoyloxy-16α-methyl-1,4,8-pregnatriene-3,11,20-trione, m.p. 159° C.

Provenance & Evidence