Bromine → Butyl 3-bromo-2-oxopentanoate

HRID 43637Notes

Reaction equation

HRID 43637 reaction equation
[O:1]=[C:2]([CH2:10][CH2:11][CH3:12])[C:3]([O:5][CH2:6][CH2:7][CH2:8][CH3:9])=[O:4].[Br:13]Br>C(Cl)(Cl)Cl>[Br:13][CH:10]([CH2:11][CH3:12])[C:2](=[O:1])[C:3]([O:5][CH2:6][CH2:7][CH2:8][CH3:9])=[O:4]

Participants

4

Reactant 2

HCID 24408BromineHCID 10888378Butyl 2-oxopentanoate

Product 1

HCID 86648534Butyl 3-bromo-2-oxopentanoateYield 99%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The same operation as in Example (106a) was performed using butyl 2-oxopentanoate (described in Cuvigny; C. R. Hebd. Seances Acad. Sci.; 240; 1955; 206, 12g, 69.8 mmol), bromine (3.33 mL, 65 mmol) and chloroform (80 mL), to obtain 16.15 g of the title compound as a colorless liquid (99%).

Sources & evidence

ORD record
ord-0d4435fe5ecb4a0faec77395c5dc3536
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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