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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43639Generated: October 28, 2026

Ethyl Acetate → HCID 86648589, compound

https://huagongshe.com/reaction/43639

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetateHCID 8857—
ReactantButyl cis(+/-)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-ethyl-1,3-oxazole-4-carboxylateHCID 86648590—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
ProductHCID 86648589HCID 86648589107.1%

Reaction Steps

The same operation as in Example (95b) was performed using butyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-ethyl-1,3-oxazole-4-carboxylate obtained in Example (110b) (0.5 g, 1.09 mmol), 10% Pd/C (0.2 g), ethyl acetate (3 mL) and methanol (3 mL), to obtain 0.38 g of the title compound as a yellow oily substance (100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-917df508cecc4ea8a5f16876cd10b3a5
Source noteuspto-grants-2013_09