2-Pyrazinecarboxylic acid → HCID 3532018, compound

Participants

Reaction Steps

3.7 G. of 2-pyrazinecarboxylic acid is suspended in 20 ml. of dry tetrahydrofuran and 6.3 g. of trifluoroacetic anhydride is added thereto. To the resulting solution, at 20°-24° C., there is added 8.5 ml. of triethylamine and 4 g. of 2-aminobenzimidazole (II) and the thus-obtained reaction mixture is stirred at 20°-25° C. for about 5 hours. 200 Ml. of water is then added, followed by filtration and the residue is recrystallized from aqueous acetic acid to yield 22-pyrazinylcarbonylamino)-benzimidazole[(III), R = 2-pyrazinyl].

Provenance & Evidence