Sulfuric Acid → HCID 12349072, compound

HRID 436439Notes

Reaction equation

HRID 436439 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][N:4]=1)[NH2:2].[C:13]1(=O)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.S(=O)(=O)(O)O>>[C:13]1(=[N:2][NH:1][C:3]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH2:6][CH2:5][N:4]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 7967CyclohexanoneHCID 123490411-Hydrazinyl-3,4-dihydroisoquinoline

Product 1

HCID 12349072HCID 12349072, compound

Procedure

In a manner similar to that of Example 4, condensation of 1-hydrazino-3,4-dihydroisoquinoline (9.4 g.) and cyclohexanone (6.3 g.) and treatment of the reaction mixture with sulfuric acid gave an oil, which was crystallized, then recrystallized, from isopropyl alcohol-ether, affording 1-(2-cyclohexylidenehydrazino)-3,4-dihydroisoquinoline [(I: X=X'=CH2 (CH2)4C,] Y=Y'=Z=Z'=H) sulfate (15.3 g., m.p. 139°-141° C. with decomposition).

Workup

  1. customgave an oil, which
  2. customwas crystallized
  3. customrecrystallized, from isopropyl alcohol-ether

Sources & evidence

ORD record
ord-6f3619faa61040a9ab2cd8de386aa463
Source dataset
uspto-grants-1977_02
Patent number
US04009170

Reaction notes

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