Triethyloxonium tetrafluoroborate → HCID 12349039, compound

Participants

Reaction Steps

In a manner similar to that of Step A of Example 1, ethylation of 4-hydroxy-3,4-dihydroisocarbostyril (21.75 g.) with triethyloxonium fluoborate (0.147 + 0.073/3 mole) and two recrystallizations (the first recrystallization afforded a first crop of 8 g., of which 4.2 g. was recrystallized) of the resulting product from ethanol-ether afforded 1-ethoxy-4-hydroxy-3,4-dihydroisoquinoline (III: Q = C2H5, Y' = OH, Y = Z = Z' = H) fluoborate (3.9 g., m.p. 121°-123° C.).

Provenance & Evidence