HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 86648596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 86648595 | HCID 86648595 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86648596 | HCID 86648596 | 90.9% |
Reaction Steps
The same operation as in Example (91d) was performed using butyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-isopropyl-1,3-oxazole-4-carboxylate obtained in Example (111d) (0.15 g, 0.30 mmol), 2 N lithium hydroxide (3 mL, 6 mmol), methanol (3 mL) and THF (5 mL), to obtain 0.12 g of the title compound as a colorless solid (90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536197B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-5136378aebaa40548e700b77367f3880 |
| Source note | uspto-grants-2013_09 |