反应详情

温度

100 °C

Methyl-5,6,7,8-tetrahydroquinoline-8-carboxylate (9 g.) was dissolved in methanol previously saturated with ammonia (270 ml.) and heated in a bomb at 100° C for 5 days. The solvent was removed and the residual oil triturated with hot petroleum ether (40°-60°). The resultant solid was filtered and then recrystallised from ethylacetate giving the title compound as colourless needles mpt. 132° C (5 g.). Found: C, 67.7; H, 7.1; N, 16.0% C10H12N2O requires: C, 68.1; H, 6.9; N, 15.9%.

1. customThe solvent was removed
2. customthe residual oil triturated with hot petroleum ether (40°-60°)
3. filtrationThe resultant solid was filtered
4. customrecrystallised from ethylacetate giving the title compound as colourless needles mpt
5. custom132° C (5 g.)