Phosphorus sulfide (P2S5) → 8-Quinolinecarbothioamide, 2-(1,1-dimethylethyl)-5,6,7,8-tetrahydro-

HRID 436475Notes

Reaction equation

HRID 436475 reaction equation
[C:1]([C:5]1[CH:14]=[CH:13][C:12]2[CH2:11][CH2:10][CH2:9][CH:8]([C:15]([NH2:17])=O)[C:7]=2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:19]>>[C:1]([C:5]1[CH:14]=[CH:13][C:12]2[CH2:11][CH2:10][CH2:9][CH:8]([C:15](=[S:19])[NH2:17])[C:7]=2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 12278969HCID 12278969, compound

Product 1

HCID 122789808-Quinolinecarbothioamide, 2-(1,1-dimethylethyl)-5,6,7,8-tetrahydro-

Procedure

The title compound was prepared from 2-t-butyl-5,6,7,8-tetrahydroquinoline-8-carboxamide (4 g.) and P2S5 (3 g.) as described in Example 8 and was isolated as creamy needles after recrystallisation from n-hexane m.p. 126° C (650 mgs.). Found: C, 68.18; H, 8.25; N, 11.14%. C14H20N2S requires C, 67.70; H, 8.12; N, 11.23%.

Workup

  1. customwas isolated as creamy needles
  2. customafter recrystallisation from n-hexane m.p. 126° C (650 mgs.)

Sources & evidence

ORD record
ord-3b0dcf0b908844fe8a465ed344291fab
Source dataset
uspto-grants-1977_02
Patent number
US04009169

Reaction notes

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