HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Phenyl-3-(3-pyrrolidinopropionyl)benzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 1-(2-Phenylbenzofuran-3-yl)ethanone | HCID 13024726 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-Phenyl-3-(3-pyrrolidinopropionyl)benzofuran | HCID 21452751 | — |
Reaction Steps
To a solution of 23.6 grams of 2-phenyl-3-acetylbenzofuran in 70 milliliters of isopropanol was added 4.2 grams of paraformaldehyde, 10 grams of pyrrolidine and 30 milliliters of a saturated solution of hydrogen chloride in ethanol and the mixture was heated under reflux at its boiling point for 10 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04009184 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-fceb410546054e4badc44089db582370 |
| Source note | uspto-grants-1977_02 |