反应详情

A suspension of N-[[(4-fluorophenyl)carbamoyl]-imino]pyridinium ylide (1.04 g) and sodium borohydride (2.55 g) in ethanol (100 ml) was stirred at ambient temperature for 16 hours. Excess of sodium borohydride was decomposed with water, and the resulting mixture was evaporated. The residue was extracted with chloroform (20 ml×3). The combined organic extract was washed with water, dried over magnesium sulfate and evaporated to give crystalls. Recrystallization from diisopropyl ether gave N-[[(4-fluorophenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine (0.60 g).

1. customthe resulting mixture was evaporated
2. extractionThe residue was extracted with chloroform (20 ml×3)
3. extractionThe combined organic extract
4. washwas washed with water
5. dry with materialdried over magnesium sulfate
6. customevaporated
7. customto give crystalls
8. customRecrystallization from diisopropyl ether