Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium formate → Tert-butyl cis(+/-)-4-amino-3-ethoxypiperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium formate | HCID 2723923 | — |
| 반응물 | tert-Butyl cis(+/-)-4-(benzylamino)-3-ethoxypiperidine-1-carboxylate | HCID 86648597 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Tert-butyl cis(+/-)-4-amino-3-ethoxypiperidine-1-carboxylate | HCID 86648467 | 77.1% |
반응 단계
The same operation as in Example (90d) was performed using tert-butyl cis(±)-4-(benzylamino)-3-ethoxypiperidine-1-carboxylate obtained in Example (112c) (4.06 g, 12.1 mmol), 10% Pd/C (wet, 1.1 g), ammonium formate (2.87 g, 46 mmol) and methanol (30 mL), to obtain 2.28 g of the title compound as a colorless oily substance (94%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536197B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-cc414890987a4abf9952ae6799d223db |
| 출처 메모 | uspto-grants-2013_09 |