HCID 53787163, compound → HCID 54015276, compound

Participants

Reaction Steps

8-(5-Dimethoxymethyl-2-furyl)-octanoic acid methyl ester (6.03 g, 0.02 mol), methanol (50 ml) and Raney nickel (3.0 g) were shaken under 100 atmospheres of hydrogen for 48 hours at 85°-100° C. After filtration, the methanol was distilled under reduced pressure from a water bath (60° C). Ether (50 ml) was added to the residue, and the turbid colourless solution was filtered. The ethereal solution was evaporated to dryness from a water bath under reduced pressure, at last under 15 mm Hg. The residual clear, colourless oil (6.07 g) was purified by distillation from a potassium acetate-coated flask giving 5.66 g (93%) of 8-(5-dimethoxymethyl-tetrahydro-2-furyl)-octanoic acid methyl ester, b0.1 126°-127° C, nD25 1.4504.

Provenance & Evidence