Acetone → HCID 53710769, compound

Participants

Reaction Steps

8-(2,5-Dimethoxy-5-dimethoxymethyl-tetrahydro-2-furyl)-octanoic acid methyl ester (1.00 g, 0.0028 mole), 20 ml of acetone and p-toluenesulfonic acid (0.002 g) were stirred for 2 hours at room temperature. The clear solution was poured into cold water (100 ml, 0° C) and extracted with two 50-ml portions of ether. The combined ethereal extracts were washed with 6% aqueous sodium hydrogen carbonate (30 ml) and then with two 50-ml portions of water, dried with magnesium sulfate, and evaporated to dryness from a water bath (60° C), at last under 15 mm Hg. The distillation of residual oil gave 0.83 g (95%) of the title compound, b0.1 154°-156° C, nD25 1.4531.

Provenance & Evidence