反应详情

15.2g (0.08 mole) of 4-acetamino-3-methyl-N-ethylaniline obtained in Example 1, Part C, 4.2g (0.09 mole) of ethylene oxide and 50ml of ethanol were fed into an autoclave and reacted for 1 hour at 120° to 130° C in the closed autoclave. Thereafter, ethanol was distilled off to obtain crystals of 4-acetamino-3-methyl-N-(β-hydroxyethyl)-N-ethylaniline. The crystals were recrystallized from ethyl acetate to obtain 18.5g of white crystals.

1. customreacted for 1 hour at 120° to 130° C in the closed autoclave
2. distillationThereafter, ethanol was distilled off