HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Sulfate → N-[4-(diethylamino)-2-methylphenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Sulfate | HCID 6163 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Acetamino-3-methyl-N-ethylaniline | HCID 21452831 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(diethylamino)-2-methylphenyl]acetamide | HCID 222177 | 64.4% |
Reaction Steps
19.1g (0.1 mole) of 4-acetamino-3-methyl-N-ethylaniline obtained in Example 1, Part C, and 100g of water were mixed, and, after 12.5g of diethyl sulfate were added dropwise thereto while stirring, the entire reaction system was stirred overnight at room temperature. Next, the reaction mixture was neutralized with sodium hydroxide and the crystals separated were recrystallized from methanol to obtain 11.5g of white crystals of 4-acetamino-3-methyl-(N,N-diethyl)aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04009205 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-07f5cee7c9e849128dbff41ea39d7b24 |
| Source note | uspto-grants-1977_02 |