Chloroacetyl chloride → HCID 20361155, compound

HRID 436555Notes

Reaction equation

HRID 436555 reaction equation
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[N:12]=[C:11]([NH:13][NH2:14])[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[C:7]=2[CH:21]=1.[Cl:22][CH2:23][C:24](Cl)=O>C(O)(=O)C>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:24]([CH2:23][Cl:22])=[N:14][N:13]=[C:11]3[CH2:10][N:9]=[C:8]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[C:7]=2[CH:21]=1

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 20361207HCID 20361207, compound

Product 1

HCID 20361155HCID 20361155, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

According to the procedure of Preparation 2, 7-methylthio-5-(2-pyridyl)-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with chloroacetyl chloride in acetic acid to give 8-methylthio-1-(chloromethyl)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-aab0f89373194609bc4c1dd7876eda43
Source dataset
uspto-grants-1977_02
Patent number
US04009175

Reaction notes

Loading…