HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(dimethylamino)methyl-8-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Dimethylhydroxylamine | HCID 27970 | — |
| Reactant | 8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s triazolo[4,3-a][1,4]benzodiazepine | HCID 20361200 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(dimethylamino)methyl-8-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 12612380 | — |
Reaction Steps
In the manner given in Example 16, a solution of N,N-dimethylhydroxylamine in dimethylformamide is treated with sodium hydride suspended in mineral oil, and the mixture is treated with 8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 8-bromo-1-[(dimethylamino)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine, N1 -oxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04009175 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-22f140d5138542e8a1a7158bd60d20b5 |
| Source note | uspto-grants-1977_02 |