HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → 8-chloro-1-[(hydroxyamino)methyl]-6-phenyl-4H-s-triazolo [4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 8-chloro-1-(chloromethyl)-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | HCID 12612345 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-chloro-1-[(hydroxyamino)methyl]-6-phenyl-4H-s-triazolo [4,3-a][1,4]benzodiazepine | HCID 20361238 | — |
Reaction Steps
In the manner given in Example 15, 8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine is treated with a cold mixture of hydroxylamine and sodium hydride in dimethylformamide to give 8-chloro-1-[(hydroxyamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04009175 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-cf5d8796dfdf4f189fcb873b24beba7c |
| Source note | uspto-grants-1977_02 |