Acetic Anhydride → HCID 53932038, compound

HRID 436613Notes

Reaction equation

HRID 436613 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=O)[CH:5]=[C:6]([I:8])[CH:7]=1.C(OC(=O)C)(=O)C.C([O-])(=O)C.[Na+]>>[I:1][C:2]1[CH:3]=[C:4]([N:9]2[C:10](=[O:17])[CH2:11][CH2:12][CH2:13][C:14]2=[O:16])[CH:5]=[C:6]([I:8])[CH:7]=1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 54124668HCID 54124668, compound

Product 1

HCID 53932038HCID 53932038, compound

Procedure

A mixture comprising 23.0 g. of N-(3,5-diiodophenyl) glutaric acid monoamide, 50 g. of acetic anhydride and 1 g. of anhydrous sodium acetate was fed to a 100 ml. four-necked flask and heated with stirring at 80° - 90° C. for 1 hour. Thereafter, the acetic acid and acetic anhydride were removed by distillation under reduced pressure, and the residue was washed with water and then dried to obtain 21.2 g. of the above-mentioned compound in the form of white crystals, m.p. 177° - 178.5° C.

Workup

  1. temperaturefour-necked flask and heated
  2. customThereafter, the acetic acid and acetic anhydride were removed by distillation under reduced pressure
  3. washthe residue was washed with water
  4. customdried
  5. customto obtain 21.2 g

Sources & evidence

ORD record
ord-84a8e4a1808c413086ce94c366e61c5c
Source dataset
uspto-grants-1977_02
Patent number
US04009278

Reaction notes

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